There are 17 varieties of crops that can mutate into new versions of themselves for a total of 172 crops: 81 crops and 81 great versions of the same crops. Some crops will trigger a mutation with very little effort on your part, but some others only mutate from already-mutated crops plus utilizing crop-specific fertilizer.
If the crop you're trying to mutate requires a special fertilizer, it must be applied at least once while the crop is growing. The mutation-triggering fertilizer doesn't need to be applied every day.
For crops that can be harvested multiple times (strawberry, corn, green pepper, hot pepper, squash, blueberry, watermelon, and asparagus), once the crop mutates into a new variety it will continue to produce the mutated crop. Regrowable crops have the chance to mutate each time they produce harvestable goods during the season they can mutate. For example, a Blueberry grown on swampy terrain during Winter (after using Berry Blend before the plant matures) might give Blueberry at first but then change to Cranberry the next time you harvest.
Crops that can be reharvested can also survive the season change if their health is high enough at the start of the new season. The Blueberry and Cranberry example from above can continue to produce well into Spring, though the Blueberry won't possibly mutate into Cranberry anymore.
Mutations
When the right conditions are met, crops can transform into new crops when they're ready to be picked. The plant's chances of mutating depends on the crop's health, the season, and the terrain. Crops that regrow (corn, green peppers, etc.) that do mutate will continue to produce the mutated crop, while one-time harvested crops (tomato, celery, etc.) will have to be planted after harvest for the mutation to possibly trigger again. When a mutation triggers, the crop or flower will visibly be different than the crops around it. The farming friend thought bubble will display a "?" crop icon if you've never harvested that particular crop mutation before.
The parent crop that triggers the mutation might need to be planted in a season it doesn't like. For example, growing Strawberry during Winter can result in the crop changing into White Berry, but Strawberry is very unhappy when forced to grow during the harsh snowy weather. This is why daily use of Fertilizer is very important in this instance, so the Strawberry will survive long enough for harvest and possibly mutate into White Berry.
After you sell a specific number of mutations to the shipping bin, Sam (for crops), or Carol (for flowers), the seed vendors will being to sell the seeds for that mutation. Many of the second-generation crops can mutate into third-generation mutations. Mutating a mutated crop typically require more stringent criteria to trigger the mutation such as high crop health and specialty fertilizer.
Spring Crop Mutations
| Name | Unlock | Terrain | Days |
| Baby Asparagus | Mutation of Asparagus on grassy, mixed, or dry terrain during Spring | Grassy, Mixed, Dry | 8 Days (Regrows) |
| Red Cabbage | Mutation of Cabbage on grassy terrain during Spring | Grassy | 4 Days |
| Huge Cabbage | Mutation of Cabbage on grassy terrain during Spring using Cabbage Fertilizer | Grassy | 8 Days |
| Scallion | Mutation of Onion on grassy terrain during Spring | Grassy | 6 Days |
| Red Zeppelin | Mutation of San Marzano on grassy terrain during Spring using Tomato Fertilizer | Grassy | 8 Days |
| Jalapeno | Mutation of Hot Pepper on grassy terrain during Spring | Grassy |
6 Days (Regrows) |
| Squash | Mutation of Pumpkin on grassy terrain during Spring | Grassy | 10 Days (Regrows) |
| Savoy Spinach | Mutation of Spinach on grassy terrain during Spring | Grassy | 5 Days |
| Dryad | Mutation of Romanesco on grassy terrain during Spring using Broccoli Fertilizer | Grassy | 11 Days |
| Magic Pepper | Mutation of Orange Pepper on mixed terrain during Spring using Pepper Fertilizer | Mixed | 10 Days (Regrows) |
| Purple Asparagus | Mutation of Asparagus on mixed terrain during Spring using Asparagus Fertilizer | Mixed | 12 Days (Regrows) |
| Purple Pepper | Mutation of Red Pepper on dry terrain during Spring | Dry | 10 Days (Regrows) |
| Petite Onion | Mutation of Scallion on dry terrain during Spring | Dry | 4 Days |
| Gold Berry | Mutation of Cranberry on dry terrain during Spring using Berry Fertilizer | Dry | 20 Days (Regrows) |
| Green Cabbage | Mutation of Red Cabbage on swampy terrain during Spring | Swampy | 6 Days |
| Magical Berry | Mutation of Angel Lantern on swampy terrain during Spring using Berry Fertilizer | Swampy | 12 Days (Regrows) |
Summer Crop Mutations
| Name | Unlock | Terrain | Days |
| Fodder Corn | Mutation of Corn on any terrain during Summer | Any | 6 Days (Regrows) |
| Sweet Corn | Mutation of Corn on any terrain during Summer | Any | 8 Days (Regrows) |
| Red Pepper | Mutation of Green Pepper on any terrain during Summer using Pepper Fertilizer | Any | 8 Days (Regrows) |
| Devil Pepper | Mutation of Habanero on any terrain during Summer using Pepper Fertilizer | Any | 8 Days (Regrows) |
| Giant Squash | Mutation of Squash on any terrain during Summer using Pumpkin Fertilizer | Any | 24 Days (Regrows) |
| Mystic Herb | Mutation of Celery on grassy terrain during Summer using Celery Fertilizer | Grassy | 8 Days |
| Red Onion | Mutation of Scallion on grassy terrain during Summer using Onion Fertilizer | Grassy | 8 Days |
| Orange Pepper | Mutation of Green Pepper on grassy terrain during Summer | Grassy | 8 Days (Regrows) |
| Princess' Eye | Mutation of Angel Lantern on mixed terrain during Summer using Berry Fertilizer | Mixed | |
| Durum Wheat | Mutation of Wheat on mixed terrain during Summer | Mixed | 4 Days |
| Cannonball | Mutation of Watermelon on mixed terrain during Summer | Mixed | 10 Days |
| San Marzano | Mutation of Tomato on dry terrain during Summer | Dry | 6 Days |
| Evergreen | Mutation of Broccolini on dry terrain during Summer | Dry | 10 Days |
| Mellow Yellow | Mutation of Watermelon on dry terrain during Summer | Dry | 8 Days |
| Golden Pepper | Mutation of Magic Pepper on swampy terrain during Summer using Pepper Fertilizer | Swampy | 12 Days (Regrows) |
| Black Potato | Mutation of Purple Potato on swampy terrain during Summer using Potato Fertilizer | Swampy | 8 Days |
| Brown Carrot | Mutation of Carrot on swampy terrain during Summer | Swampy | 5 Days |
| Zucchini | Mutation of Pumpkin on swampy terrain during Summer | Swampy | 8 Days (Regrows) |
Fall Crop Mutations
| Name | Unlock | Terrain | Days |
| Angel Lantern | Mutation of White Berry on any terrain during Fall | Any | 8 Days (Regrows) |
| Giant Potato | Mutation of Potato on any terrain during Fall | Any | 10 Days |
| Gooseberry | Mutation of Cranberry on any terrain during Fall | Any | 12 Days (Regrows) |
| Pearl Onion | Mutation of Petite Onion on grassy terrain during Fall | Grassy | 8 Days |
| Barley | Mutation of Wheat on grassy terrain during Fall | Grassy | 6 Days |
| Broccolini | Mutation of Broccoli on grassy terrain during Fall | Grassy | 5 Days |
| Habanero | Mutation of Hot Pepper on mixed terrain during Fall | Mixed | 6 Days (Regrows) |
| Killer Tomato | Mutation of Crimson on dry terrain during Fall using Tomato Fertilizer | Dry | |
| Sunset Corn | Mutation of Fodder Corn on dry terrain during Fall using Corn Fertilizer | Dry | 8 Days (Regrows) |
| Mandrake | Mutation of Brown Carrot on dry terrain during Fall using Carrot Fertilizer | Dry | 7 Days |
| Giant Pumpkin | Mutation of Giant Sqush on dry terrain during Fall using Pumpkin Fertilizer | Dry | 18 Days (Regrows) |
| Kegling | Mutation of Cannonball on dry terrain during Fall using Melon Fertilizer. Must plant in a checkerboard pattern. | Dry | |
| Phalax | Mutation of Purple Asparagus on dry terrain during Fall using Asparagus Fertilizer | Dry | 16 Days (Regrows) |
| Lilac Spinach | Mutation of Savoy Spinach on swampy terrain during Fall | Swampy | 6 Days |
Winter Crop Mutations
| Name | Unlock | Terrain | Days |
| White Celery | Mutation of Celery on any terrain during Winter | Any | 6 Days |
| White Berry | Mutation of Strawberry on any terrain during Winter. | Any | 8 Days (Regrows) |
| Crimson | Mutation of Tomato on any terrain during Winter using Tomato Fertilizer | Any | |
| Dragon Pepper | Mutation of Jalepeno on any terrain during Winter using Pepper Fertilizer | Any | 8 Days (Regrows) |
| Cream Pumpkin | Mutation of Squash on mixed or dry terrain during Winter | Mixed, Dry | 12 Days (Regrows) |
| Romanesco | Mutation of Broccolini on any terrain during Winter using Broccoli Fertilizer | Any | 9 Days |
| Dome Cabbage | Mutation of Huge Cabbage on grassy terrain during Winter using Cabbage Fertilizer | Grassy | |
| Yellow Corn | Mutation of Sweet Corn on grassy terrain during Winter | Grassy | 8 Days (Regrows) |
| White Pepper | Mutation of Magic Pepper on grassy terrain during Winter | Grassy | 8 Days (Regrows) |
| Baby Carrot | Mutation of Carrot on grassy terrain during Winter | Grassy | 3 Days |
| White Carrot | Mutation of Baby Carrot on grassy terrain during Winter using Carrot Fertilizer | Grassy | 7 Days |
| Black Current | Mutation of Blueberry on grassy terrain during Winter | Grassy | 15 Days (Regrows) |
| Royal Herb | Mutation of White Celery on mixed terrain during Winter using Celery Fertilizer | Mixed | 8 Days |
| Purple Potato | Mutation of Potato on mixed terrain during Winter using Potato Fertilizer | Mixed | 5 Days |
| Pink Spinach | Mutation of Baby Spinach on mixed terrain during Winter using Spinach Fertilizer | Mixed | 7 Days |
| Rye | Mutation of Barley on dry terrain during Winter using Wheat Fertilizer | Dry | 4 Days |
| Titan Potato | Mutation of Black Potato on dry terrain during Winter using Potato Fertilizer | Dry | |
| Teardrop | Mutation of Red Onion on swampy terrain during Winter using Onion Fertilizer | Swampy | |
| Baby Spinach | Mutation of Spinach on swampy terrain during Winter using Spinach Fertilizer | Swampy | 4 Days |
| Cranberry | Mutation of Blueberry on swampy terrain during Winter using Berry Fertilizer | Swampy | 12 Days (Regrows) |
| Snowman | Mutation of Mellow Yellow on swampy terrain during Winter using Melon Fertilizer | Swampy |